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I thought you'd enjoy this article by Lara Pizzorno, MDiv, MA, LMT on Longevity Medicine Review:

http://www.lmreview.com/articles/view/advanced-glycated-end-products-ages

Advanced glycated end-products (AGEs) form as a result of a non-enzymatic reaction in which glucose forms adducts with proteins, lipids and nucleic acids. AGEs accumulate naturally as a result of chronological aging, but this process is greatly accelerated under conditions of hyperglycemia and oxidative stress. AGEs directly induce cross-linking of long-lived proteins, such as collagen and elastin in the extracellular matrix, thus promoting stiffness and compromising vascular structure and function. In addition, AGEs interact with specific AGE receptors on virtually all cell types (RAGE), inducing intracellular signaling that increases oxidative stress and the production of key pro-inflammatory and pro-sclerotic cytokines. AGEs therefore play a central role in diabetes-related pathology, cardiovascular disease, the deterioration associated with chronological aging. This review summarizes endogenous and exogenous factors involved in AGE accumulation; AGEs' involvement in cardiovascular disease, diabetic complications, and Alzheimer's disease; and the research on new anti-AGE-ing therapeutic agents, among which alagebrium (ALT-711) appears to be the safest and most effective.

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Lara Pizzorno is a member of the American Medical Writers Association with 25+ years of experience writing for physicians and the public, Lara is Editor for Longevity Medicine Review as well as Senior Medical Editor for SaluGenecists, Inc. Read more...

Lara Pizzorno, MDiv, MA, LMT

John Morgenthaler has been active in the field of nutritional medicine since 1986. Today, John travels the world looking for breakthrough nutraceuticals and anti-aging therapies. He also continues to publish cutting-edge nutrition and medical science books and periodicals. Read more...

John Morgenthaler, Publisher

Longevity Medicine Review - Analyzing the latest research in longevity science

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