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I thought you'd enjoy this article by Lara Pizzorno, MDiv, MA, LMT on Longevity Medicine Review:

http://www.lmreview.com/articles/view/beyond-tocopherol-a-review-of-natural-vitamin-es-therapeutic-potential-in-human-health-and-disease-part-I

A widely reported meta-analysis, published in the Annals of Internal Medicine in 2005, found that, while doses of vitamin E < 200 IU had no negative effects, high-dose vitamin E, defined as ≥ 400 IU per day, resulted in a small but significant (4%) increase in all-cause mortality. Despite the uncritical press coverage given this meta-analysis, the conclusions promulgated are not only highly misleading regarding true vitamin E, but insupportable for a number of reasons discussed in this article. In addition to several methodological failings not only within the studies themselves, but in the choice of studies for review, the key issue is that (primarily synthetic) α-tocopherol was used, not the full complement of isomers that constitute vitamin E. Given alone, high dose α-tocopherol may become a pro-oxidant, dysregulate key detoxification enzymes and immune function, and promote inflammation. A negative result is the logical outcome of anything other than short-term high dose α-tocopherol supplementation. However, a robust and rapidly growing body of current research, discussed in here and in Part II of this article, indicates that supplementation with natural vitamin E (i.e., mixed tocopherols and tocotrienols) is not only safe, but offers significant therapeutic potential for human health.

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Lara Pizzorno is a member of the American Medical Writers Association with 25+ years of experience writing for physicians and the public, Lara is Editor for Longevity Medicine Review as well as Senior Medical Editor for SaluGenecists, Inc. Read more...

Lara Pizzorno, MDiv, MA, LMT

John Morgenthaler has been active in the field of nutritional medicine since 1986. Today, John travels the world looking for breakthrough nutraceuticals and anti-aging therapies. He also continues to publish cutting-edge nutrition and medical science books and periodicals. Read more...

John Morgenthaler, Publisher

Longevity Medicine Review - Analyzing the latest research in longevity science

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