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I thought you'd enjoy this article by Lara Pizzorno, MDiv, MA, LMT on Longevity Medicine Review:

http://www.lmreview.com/articles/view/slowing-telomere-attrition-and-cellular-senescence-today-part-I

Cellular senescence, although protective when triggered in cells that have become cancerous, plays a key pathological role in other age-associated diseases and in so-called "healthy aging." The age-associated increase in cellular senescence has been assumed to result from the cumulative effects of "wear and tear," but genetic research has revealed that cellular senescence occurs only when cells permit it by altering their gene expression to down-regulate repair mechanisms. Aging occurs not because our genes lose their capacity to restore health, but because of alterations in patterns of gene expression that result in inadequate responses to oxidative damage. These alterations are triggered by the loss of the protective caps at the ends of chromosomes called telomeres, which occurs with each round of DNA replication. Telomere shortening, not the "wear and tear" of oxidative damage, is the proximate activator of the cellular switch for replicative senescence. Research investigating the anti-aging potential of telomere manipulation has focused on the insertion of a new gene for telomerase, the enzyme that renews telomeres, but this strategy may increase oncogenic risk and remains at least a decade away from clinical use. Fortunately, a rapidly growing body of research is revealing that telomere length and attrition rate can be directly affected by environmental and lifestyle factors, which we can impact right now. This article reviews the research on these modifiable factors, which have been shown to significantly attenuate telomere attrition.

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Lara Pizzorno is a member of the American Medical Writers Association with 25+ years of experience writing for physicians and the public, Lara is Editor for Longevity Medicine Review as well as Senior Medical Editor for SaluGenecists, Inc. Read more...

Lara Pizzorno, MDiv, MA, LMT

John Morgenthaler has been active in the field of nutritional medicine since 1986. Today, John travels the world looking for breakthrough nutraceuticals and anti-aging therapies. He also continues to publish cutting-edge nutrition and medical science books and periodicals. Read more...

John Morgenthaler, Publisher

Longevity Medicine Review - Analyzing the latest research in longevity science

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