http://www.lmreview.com/articles/ en lara@smart-publications.com Copyright 2011 2011-12-06T22:34:17+00:00 http://www.lmreview.com/articles/view/adrenal-fatigue-the-21st-century-stress-syndrome/ http://www.lmreview.com/articles/view/adrenal-fatigue-the-21st-century-stress-syndrome/#When:21:34:17Z In Adrenal Fatigue, Dr. James Wilson combines a researcher’s grasp of the latest scientific insights into the causes of adrenal dysfunction with an experienced clinician’s practical understanding of its real life impact on patients. The result is a book that successfully bridges the gap between the therapeutic lifestyle changes the research shows must occur to restore adrenal function and the support clinicians can provide to enable patients to actually make these changes. Book Reviews 2011-12-06T21:34:17+00:00 http://www.lmreview.com/articles/view/Vitamin-K2-Essential-for-Prevention-of-Age-Associated-Chronic-Disease/ http://www.lmreview.com/articles/view/Vitamin-K2-Essential-for-Prevention-of-Age-Associated-Chronic-Disease/#When:19:43:18Z Sufficiency of vitamin K, as K2 specifically, is gaining recognition as a requirement for long term health in many more areas of human physiology Latest Research 2011-08-02T19:43:18+00:00 http://www.lmreview.com/articles/view/l-citrulline-restoring-erectile-function-viagra-doesnt/ http://www.lmreview.com/articles/view/l-citrulline-restoring-erectile-function-viagra-doesnt/#When:21:48:14Z L-citrulline corrects the cause of ED, PDE5-inhibitors do not. Learn more now... Latest Research 2011-04-21T21:48:14+00:00 http://www.lmreview.com/articles/view/Selecting-the-Right-Hormone-Tests-for-Your-Male-Patient/ http://www.lmreview.com/articles/view/Selecting-the-Right-Hormone-Tests-for-Your-Male-Patient/#When:19:49:43Z For the male patient, hormones can be assayed using saliva, blood (serum), and urine. Which of the three hormone test methods, or which combination of tests, you will wish to utilize will depend upon what information you require in a given clinical situation. Latest Research 2011-03-11T19:49:43+00:00 http://www.lmreview.com/articles/view/select-the-right-hormone-test-for-your-patient-using-bio-identical-hormone-/ http://www.lmreview.com/articles/view/select-the-right-hormone-test-for-your-patient-using-bio-identical-hormone-/#When:17:04:22Z Part I: The Advantages and Disadvantages of Saliva, Serum and Urine Tests Treating the sequelae of the age- and stress-related decline in adult hormones with bio-identical hormone replacement (BHRT) can restore more youthful hormone levels and significantly alleviate symptoms associated with “normal” aging, optimizing health, happiness and quality of life. Successful and safe BHRT, however, necessitates laboratory testing to assess the patient’s current hormonal status, monitor treatment, and ensure that hormones are being metabolized in ways that reduce risks for cancer, cardiovascular disease, osteoporosis, other age-related diseases and declines in cognitive and sexual function. Hormones can be assayed using saliva, blood (serum), and urine. Each testing method has advantages and disadvantages. Which of the three hormone test methods, or which combination of tests, you will wish to utilize will depend upon what information. you need in a given clinical situation. Latest Research 2010-12-03T17:04:22+00:00 http://www.lmreview.com/articles/view/glucosamine-sulphate-but-not-glucosamine-hydrochloride-effective-against-os/ http://www.lmreview.com/articles/view/glucosamine-sulphate-but-not-glucosamine-hydrochloride-effective-against-os/#When:14:29:17Z Clarification is in order for the widely publicized findings of a recent BMJ article entitled: Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of the hip or knee: network meta-analysis. The headline of the September 13, 2010, press release declaims: Popular supplements to combat joint pain do not work. Latest Research 2010-10-11T14:29:17+00:00 http://www.lmreview.com/articles/view/calcium-supplements-increase-risk-of-mi-the-one-variable-emperor-is-naked/ http://www.lmreview.com/articles/view/calcium-supplements-increase-risk-of-mi-the-one-variable-emperor-is-naked/#When:14:20:13Z A meta-analysis published in the July 29, 2010 issue of the British Medical Journal deserves special mention for exemplifying—to the point that one wonders if the subtext is to point out the idiocy of our current research paradigm—the shortcomings of the “isolate one variable” approach to studying human physiology or providing dietary supplements for real human beings. Latest Research 2010-08-19T14:20:13+00:00 http://www.lmreview.com/articles/view/resveratrol-niacin-nicotinamide-riboside-key-players-in-activating-sirtuins-to-mimic-calorie-restriction-extend-lifespan-part-ii/ http://www.lmreview.com/articles/view/resveratrol-niacin-nicotinamide-riboside-key-players-in-activating-sirtuins-to-mimic-calorie-restriction-extend-lifespan-part-ii/#When:22:31:23Z In just the last 30 years, molecular biologists have discovered genes with the potential to extend longevity: SIR2 in yeast and its mammalian equivalent, SIRT1. In animal models, SIRT1, via the enzymes it encodes, has been shown to have healthspan extending regulatory effects on metabolism, stress resistance, cellular survival, cellular senescence, inflammation-immune function, endothelial function, and circadian rhythms. Clinically relevant findings first began to appear in the peer-reviewed medical literature a mere 10 years ago with the revelation that the keys that unlock and activate our longevity genes are naturally occurring dietary polyphenols. Part II of this review details SIRT1’s anti-aging effects via an overview of the primary functions of key regulatory proteins deacetylated by Sirt1 and the mitochondrial sirtuins (sirtuins 3-5). Even the brief overview provided demonstrates why the sirtuins, nicknamed “the magnificent seven” have also been dubbed “the master switches of metabolism.” Although resveratrol’s beneficial effects are primarily mediated through its activation of SIRT1, resveratrol’s cellular targets also include a number of other important regulatory enzymes including cyclooxygenases, lipooxygenases, kinases, ribonucleotide reductase, adenylyl cyclase, aromatase and DNA polymerases. The potential impact on healthspan of resveratrol’s modulation of the activity of these extra-sirtuin targets is outlined. Lastly, a number of other naturally occurring dietary polyphenols have lately been recognized to be sirtuin activating compounds (STACs); these, and their common mechanism of action, are noted. We have entered a new era in which the key genes and intracellular pathways responsible for aging and longevity have been identified. Our discovery of the sirtuins – and the fact that their activity is responsive to changes in cellular metabolism and a number of xenohormetic plant compounds –has proven that lifespan is tractable. Not only is the research progressing at an exponential rate, but, right now—today, we can safely utilize emerging knowledge to develop effective longevity-enhancing protocols. Latest Research 2010-08-09T22:31:23+00:00 http://www.lmreview.com/articles/view/resveratrol-niacin-nicotinamide-riboside-key-players-in-activating-sirtuins-to-mimic-calorie-restriction-extend-lifespan-part-i/ http://www.lmreview.com/articles/view/resveratrol-niacin-nicotinamide-riboside-key-players-in-activating-sirtuins-to-mimic-calorie-restriction-extend-lifespan-part-i/#When:20:06:57Z In just the last 30 years, molecular biologists have discovered genes with the potential to extend longevity: SIR2 in yeast and its mammalian equivalent, SIRT1. In animal models, SIRT1, via the enzymes it encodes, has been shown to have healthspan extending regulatory effects on metabolism, stress resistance, cellular survival, cellular senescence, inflammation-immune function, endothelial function, and circadian rhythms. Clinically relevant findings first began to appear in the peer-reviewed medical literature a mere 10 years ago with the revelation that the keys that unlock and activate our longevity genes are naturally occurring dietary polyphenols. Part I of this review highlights key historical high points of the research odyssey that cracked the longevity code and provides the reader with a backstage pass to meet the enzymes encoded by SIRT1—the seven nutrient-responsive NAD+-dependent histone deacetylase enzymes, dubbed the sirtuins. Part I’s interview with these intriguing enzymes provides answers to the following questions: What are the unique nutrient requirements of the sirtuins? How and why is their activation impacted not only by calorie restriction, but by certain phytonutrients such as resveratrol, and by the redox state of the cell, specifically its NAD+/NAD(H) ratio? What can be done to optimize this ratio via NAD+ salvage, and why will this—in conjunction with resveratrol and/or other SIRT1-activating compounds--optimize sirtuin activity? Why might a very recently discovered niacin-related compound, nicotinamide riboside, be a better sirtuin-activating partner for resveratrol than niacin (nicotinic acid) or its derivative, niacinamide? Latest Research 2010-08-09T20:06:57+00:00 http://www.lmreview.com/articles/view/getting-off-the-alzheimers-disease-interstate-part-ii/ http://www.lmreview.com/articles/view/getting-off-the-alzheimers-disease-interstate-part-ii/#When:20:34:41Z A clear association has been well documented in the peer-reviewed medical literature between lifestyle habits—diet, intake of specific micronutrients, and exercise--and the occurrence of Alzheimer’s disease . This review summarizes key, clinically relevant, findings. Latest Research 2010-05-14T20:34:41+00:00